We study the disconjugacy of the fourth order linear ordinary
differential equation
on the interval 
![$[a,\,b].$](img23.png)
 We find necessary and sufficient
conditions for the disconjugacy  on 
![$[a,\,b]$](img24.png)
, which have the
comparison theorems character. Our results complete  Kondrat'ev's
second comparison theorem for the case of the  fourth order ODE. The
above mentioned conditions significantly improve Coppel's well-known
condition which guarantees the disconjugacy of our equation for not
necessarily constant sign coefficient 

 and generalise  some
optimal disconjugacy results proved for constant-coefficient
equations.